By John H. Byrne, Ruth Heidelberger, M. Neal Waxham

An realizing of the apprehensive procedure at almost any point of research calls for an figuring out of its uncomplicated development block, the neuron. The 3rd version of From Molecules to Networks offers the forged origin of the morphological, biochemical, and biophysical homes of nerve cells. in line with prior variations, the original content material specialise in mobile and molecular neurobiology and similar computational neuroscience is maintained and improved.

All chapters were completely revised for this 3rd version to mirror the numerous advances of the prior 5 years. the hot version expands at the community points of mobile neurobiology by way of including new insurance of particular examine equipment (e.g., patch-clamp electrophysiology, together with purposes for ion channel functionality and transmitter unencumber; ligand binding; structural equipment comparable to x-ray crystallography).

Written and edited by means of prime specialists within the box, the 3rd version thoroughly and comprehensively updates all chapters of this exact textbook and insures that each one references to basic examine characterize the most recent results.

    * the 1st remedy of mobile and molecular neuroscience that incorporates an creation to mathematical modeling and simulation approaches

      * eighty% up-to-date and new content material

        * New bankruptcy on "Biophysics of Voltage-Gated Ion Channels"

          * New bankruptcy on "Synaptic Plasticity"

              * encompasses a bankruptcy at the Neurobiology of Disease

                * hugely referenced, finished and quantitative

                  * complete colour, specialist photographs throughout

                    * All images come in digital model for educating purposes

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                      Additional info for From molecules to networks : an introduction to cellular and molecular neuroscience

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                      2). The significance of microtubule diversity is incompletely understood, but may include functional differences as well as variations in assembly and stability. In particular, MAP composition may define specific neuronal domains. For example, MAP-2 is restricted to dendritic regions of the neuron, whereas tau proteins are modified differentially in axons. , 4-repeat MAP-2c or MAP-2d. This MAP is in cell bodies but not in processes suggesting a different role than MAP-2 in dendrites (Vouyiouklis and Brophy, 1995).

                      However, many serines and threonines subject to O-linked glycosylation would also be good sites for phosphorylation by various kinases, raising the possibility that glycosylation and phosphorylation of some cytoplasmic proteins may serve complementary functions. Summary Membrane biogenesis and protein synthesis in neurons and glial cells are accomplished by mechanisms worked out in other cell types. Integral membrane proteins are synthesized in the rough endoplasmic reticulum, and peripheral membrane proteins are products of cytoplasmic-free ribosomes associated with the cytoskeleton.

                      Because most proteins that move from the RER through the secretory pathway do so by default, any resident endoplasmic reticulum proteins must be restrained from exiting or returned promptly to the RER from the CGN should they escape. Although no retention signal has been demonstrated for the endoplasmic reticulum, two retrieval signals have been identified: a Lys-AspGlu-Leu or KDEL sequence in type I proteins and the Arg-Arg or RR motif in the first five amino acids of proteins with a type II orientation in the membrane.

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