By Jörg König (auth.), Martin F. Fromm, Richard B. Kim (eds.)

It is more and more famous that a number of transporter proteins are expressed during the physique and confirm absorption, tissue distribution, biliary and renal removal of endogenous compounds and medicine and drug results. This ebook will provide an summary at the transporter households that are most crucial for drug remedy. so much chapters will specialise in one transporter relations highlighting tissue expression, substrates, inhibitors, knock-out mouse versions and scientific studies.

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4 Species Differences, Age and Gender Dependence of Expression . . . . . . . . . 5 Factors Influencing Activity and Abundance of OAT2/Oat2 . . . . . . . . . . . 6 Substrates . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 Inhibitors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 Drug/Drug Interactions . . . . . . .

Drug Metab Dispos 32:291–294 Nozawa T, Suzuki M, Takahashi K, Yabuuchi H, Maeda T, Tsuji A, Tamai I (2004c) Involvement of estrone-3-sulfate transporters in proliferation of hormone-dependent breast cancer cells. J Pharmacol Exp Ther 311:1032–1037 Nozawa T, Minami H, Sugiura S, Tsuji A, Tamai I (2005) Role of organic anion transporter OATP1B1 (OATP-C) in hepatic uptake of irinotecan and its active metabolite, 7-ethyl-10- Uptake Transporters of the Human OATP Family 27 hydroxycamptothecin: in vitro evidence and effect of single nucleotide polymorphisms.

W392I; OATP2B1*2) was not found in the investigated Japanese population and the occurrence of this polymorphism needs to be verified in other ethnicities. Mougey et al. Arg312Gln) and found that this variant is associated with reduced plasma concentrations of the leukotriene receptor antagonist Montelukast. OATP1A2 (formerly termed OATP-A or OATP, gene symbol SLCO1A2) was the first human OATP family member to be cloned (Kullak-Ublick et al. 1995) and functionally characterized. SLCO1A2 mRNA expression has been detected in various tissues with a high expression in brain (Gao et al.

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