By M. Mercier (Auth.)

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The concentration of DDT plus DDE in the fat tended to reach a plateau (at about one year for the higher dose, sooner at the lower dose) when the intake was equal to the amount being meta­ bolised and/or excreted. 3. Stored DDT is progressively converted to the more innocuous derivative DDE which is stored together with the residual DDT. , 1969). 5 mg/kg/day affected glucuronyl transferase and reduced the plasma bilirubin level to normal values and this relieved the patients of the nausea and malaise.

1962 ; Czegledi-Janko and Avar, 1970 ; Jager, 1970). , 1960). 3 mg/kg 8 hrs with the addition of dermal absorption. Dermatitis, diges­ tive troubles, asthenia, and irritation of the respiratory mucosa and conjuctiva were observed. The symptoms disappeared 3 to 4 weeks after discontinuing work. In a careful examination of the electro-encephalograms of 73 wor­ kers who had been continuously exposed to chlorinated hydrocarbon insecticides, including DDT, BHC and benzilan for periods varying between 1 month and 20 years abnormal records were reported in 16 cases (22 %) (Mayersdorf and Israeli,1974).

Under the usual working conditions, the daily absorption of HCH induced clinical, chromaxometric, biochemical and haematological disturbances in 42,5 % of the workers. 56 From the clinical point of view, chronic poisoning by HCH was characterized by neurological (polyneuritis), gastro-intestinal (dyspepsia), cutaneous and respiratory disturbances. 46 % of the workers developed one or more of these symptoms. Neurological disturbances were the most frequent and appeared in 80 % of cases. Of the workers who developed clinical manifestations 84 % presen­ ted chromaxometric disturbances.

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