By CIBA Foundation Symposium

Contemporary software of the suggestions of molecular biology and patch-clamp body structure has resulted in quick advances in realizing the molecular occasions in chemosensory transduction. during this publication, the most recent effects are provided and mentioned via major scientists. The vast insurance encompasses many very important issues, together with mucous domain names; microchemical heterogeneity within the mucociliary complicated of the olfactory epithelium; membrane currents and mechanisms of olfactory transduction, and genetic and pathological style edition.

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Margolis: The only hint that I am aware of is from some results reported by Gesteland et a1 (1982) that suggest the olfactory neuroepithelial sheet has relatively low specificity, as though the immature neurons respond to a large variety of odours and that subsequently the specificity seems to become more narrowly tuned and selective. Caprio: But what are the criteria you use to decide whether a neuron is immature or mature? Margolis: The description of a neuron as immature is indicated by its position in the epithelium and by the expression of B5O/GAP-43, which is a molecular marker for immature neurons.

That is, Orf-2 could either be the gene that turns on high levels of expression of OMP about the time that synaptic connection is made, or it may be the first event which causes a small level of OMP expression and 24 Discussion then there’s a subsequent event, which could be transcriptional or translational, that raises expression 10- or 100-fold in each individual cell. It may be true for receptors as well, that there is a low and broad expression that then increases in response to some environmental control.

For instance, tyrosine hydrolase and substance P levels change. So in this system as well, there’s information going both ways. The question is: what is the information and what is its molecular basis? Caprio: There is a relatively simple experiment one can do to answer some of these questions concerning the chemical specificity of young olfactory receptor neurons. Assuming that one accepts the EOG or integrated multiunit activity as an indicator of the specificity of a population of olfactory receptors, you simply determine the olfactory specificity of an adult animal, transect the olfactory nerve and look to see whether there are changes in chemical specificity both during the time of receptor renewal and subsequent to synaptic connections within the olfactory bulb.

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