By Lisa M. Schwiebert

This quantity within the present themes in Membranes sequence discusses the biology of chemokines and their binding companions, chemokine receptors, in basic and disease-related states. Chemokines are small proteins which are very important in common immune responses. contemporary study demonstrates a task for those proteins in quite a few illnesses similar to center sickness, hypersensitive reaction, bronchial asthma, and melanoma. due to the discovery of this hyperlink to sickness, the subject of chemokines and medication that block their activities has turn into an extreme are of research. This e-book offers the themes of chemokines, chemokine receptors, and comparable pathologies in an built-in demeanour that offers the reader with a finished and up to date wisdom of those subject matters.

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Agadjanyan, M. , and Weiner, D. B. (1999). Intracellular adhesion molecule‐1 modulates beta‐chemokines and directly costimulates T cells in vivo. J. Clin. Invest. 103, 869–877. , Tiffany, H. , Murphy, P. , and Yoshie, O. (1996). Molecular cloning of human eotaxin, an eosinophil‐selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3. J. Biol. Chem. 271, 7725–7730. Klein, R. , Williams, K. , Lackner, A. , and Luster, A. D. (1999). Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: Implications for the neuropathogenesis of AIDS.

And Westwick, J. (1996). Regulation and expression of chemokines: Potential role in glomerulonephritis. J. Leukoc. Biol. 59, 75–80. , Aman, M. , and Peschel, C. (1998). Induction of macrophage‐ inflammatory protein 1alpha (MIP‐1alpha) by interferon‐alpha. Exp. Hematol. 26, 117–123. Campbell, J. , Siani, M. , Thompson, D. , and Butcher, E. C. (1998). Chemokines and the arrest of lymphocytes rolling under flow conditions. Science 279, 381–384. Castor, C. , Miller, J. , and Walz, D. A. (1983). Structural and biological characteristics of connective tissue activating peptide (CTAP‐III), a major human platelet‐derived growth factor.

59, 75–80. , Aman, M. , and Peschel, C. (1998). Induction of macrophage‐ inflammatory protein 1alpha (MIP‐1alpha) by interferon‐alpha. Exp. Hematol. 26, 117–123. Campbell, J. , Siani, M. , Thompson, D. , and Butcher, E. C. (1998). Chemokines and the arrest of lymphocytes rolling under flow conditions. Science 279, 381–384. Castor, C. , Miller, J. , and Walz, D. A. (1983). Structural and biological characteristics of connective tissue activating peptide (CTAP‐III), a major human platelet‐derived growth factor.

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