By Gary D. Lopaschuk, Naranjan S. Dhalla
The middle has a truly excessive power call for yet little or no strength reserves. with a purpose to maintain contractile functionality, the center has to continually produce a large number of ATP. the center makes use of loose fatty acids frequently and carbohydrates to some degree as substrates for making strength and any switch during this power offer can heavily compromise cardiac functionality. It has emerged that changes in cardiac power metabolism are an immense contributor to the advance of a couple of assorted different types of middle sickness. it's also referred to now that optimizing power metabolism within the middle is a doable and critical method of treating quite a few varieties of middle disease.
Cardiac strength Metabolism in future health and Disease describes the study advances which were made in realizing what controls cardiac strength metabolism at molecular, transcriptional and physiological degrees. It additionally describes how adjustments in strength metabolism give a contribution to the advance of center disorder and the way optimization of strength metabolism can be utilized to regard center affliction. the themes coated contain a dialogue of the results of myocardial ischemia, diabetes, weight problems, hypertrophy, middle failure, and genetic issues of mitochondrial oxidative metabolism on cardiac energetics. The therapy of middle affliction through optimizing strength metabolism can also be mentioned, together with expanding total power construction in addition to expanding the potency of strength construction and switching strength substrate choice of the guts. This publication can be a invaluable resource of data to graduate scholars, postdoctoral fellows, and investigators within the box of experimental cardiology in addition to biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and different healthiness professionals.
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Additional resources for Cardiac Energy Metabolism in Health and Disease
Shirpoor A, Salami S, Khadem-Ansari MH et al (2009) Cardioprotective effect of vitamin E: rescues of diabetes-induced cardiac malfunction oxidative stress and apoptosis in rat. J Diabetes Complications 23:310–316 100. Toraason M, Wey H, Woolery M et al (1995) Arachidonic acid supplementation enhances hydrogen peroxide induced oxidative injury of neonatal rat cardiac myocytes. Cardiovasc Res 29:624–628 101. Qin F, Shite J, Liang CS (2003) Antioxidants attenuate myocyte apoptosis and improve cardiac function in CHF: association with changes in MAPK pathways.
2 ApoE ApoE is present in chylomicrons, VLDL, IDL, LDL and HDL and is recognized by lipoprotein receptors, such as LDL receptor (LDLr) , LDL receptor relate protein (LRP)-1 , VLDL receptor (VLDLr) , ApoE receptor 2 , SR-BI [30, 20 K. J. Goldberg Classes of lipoprotein receptors LDL receptor family Chylo remnant Scavenger receptors Other O VLDL OH LDL O OH HDL S 1 P VLDLr VLDLr LRP Chylo remnant LRP CD36 LDLr O VLDL OH Triglyceride Retinyl-ester Cholesteryl-ester SR-BI S1PR oxLDL LOX-1 Cardiomyocyte survival Stat3 activation Cardiac repolarization Angiotensin II receptor inhibition O OH Retinoic Acid Mitochondria RxR activation Fatty acid oxidation O SCoA NF-KB, JNK and p38 signaling Reactive oxygen species Apoptosis Cardiomyocyte damage Fig.
Somers SJ, Frias M, Lacerda L et al (2012) Interplay between SAFE and RISK pathways in sphingosine-1-phosphate-induced cardioprotection. Cardiovasc Drugs Ther 26:227–237 127. Chokshi A, Drosatos K, Cheema FH et al (2012) Ventricular assist device implantation corrects myocardial lipotoxicity reverses insulin resistance and normalizes cardiac metabolism in patients with advanced heart failure. Circulation 125:2844–2853 128. Boudina S, Abel ED (2007) Diabetic cardiomyopathy revisited. Circulation 115:3213–3223 129.