By Raphael Mechoulam

Just a couple of years in the past the endocannabinoid process used to be unknown. this day we're acutely aware that endocannabinoids are desirous about a few of the capabilities of the mammalian physique - in neuroprotection, urge for food and suckling, ache, copy, nervousness, reminiscence, bone formation and so on. This quantity offers an updated photo of a few of the most important fields of endocannabinoid examine. It summarizes the activities of the endocannabinoids on quite a few physiological platforms and opens new healing home windows to numerous diseases.The first bankruptcy, at the use of hashish in India, might be seen as an expression of due to the natural practitioners, who for hundreds of years handed at the scientific traditions linked to the drug. The bankruptcy on chemistry is a brief precis of lively plant, man made and endogenous cannabinoids being investigated this day, a lot of that are pointed out later within the ebook. Cannabidiol is an strange cannabinoid - it doesn't bind to the identified receptors and but exerts numerous results. as a result a bankruptcy is dedicated to it. additional chapters take care of the endocannabinoid procedure and the endocannabinoids in a number of stipulations and physiological structures. The concluding bankruptcy describes the examine performed on Sativex®, a standardized plant extract, almost immediately to be brought in Canada as a drug for a number of sclerosis.The meant viewers is drug researchers (medicinal chemists, pharmacologists, clinicians), neuroscientists, physiologists, and clinicians drawn to the impact of the endocannabinoid method in a number of physiological platforms.

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These were recently reviewed by Hertzog [104]. O. Hanusˇ and R. Mechoulam Novartis AG has recently filed a patent application on a series of quinazolines as cannabinoid agonists useful for the treatment of pain, osteoarthritis, rheumatoid arthritis and glaucoma, among other indications [105]. Compound 1 binds to both CB1 (Ki = 34 nM) and CB2 (Ki = 11 nM). The patent application refers to the compound as having CB2 agonist activity. 5 mg/kg. Structure 15 The University of Connecticut has disclosed a series of indazole derivatives that have been found to act as agonists of cannabinoid receptors [106].

O. Hanusˇ and R. Mechoulam Novartis AG has recently filed a patent application on a series of quinazolines as cannabinoid agonists useful for the treatment of pain, osteoarthritis, rheumatoid arthritis and glaucoma, among other indications [105]. Compound 1 binds to both CB1 (Ki = 34 nM) and CB2 (Ki = 11 nM). The patent application refers to the compound as having CB2 agonist activity. 5 mg/kg. Structure 15 The University of Connecticut has disclosed a series of indazole derivatives that have been found to act as agonists of cannabinoid receptors [106].

International Cannabinoid Research Society, Cornwall, ON, Canada, 25 114 Douthwaite AH (1947) Choice of drugs in the treatment of duodenal ulcer. Brit Med J 2: 43–47 115 Tambe Y, Tsujiuchi H, Honda G, Ikeshiro Y, Tanaka S (1996) Gastric cytoprotection of the non-steroidal anti-inflammatory sesquiterpene, beta-caryophyllene. Planta Med 62: 469–470 116 Schnelle M, Grotenhermen F, Reif M, Gorter RW (1999) [Results of a standardized survey on the 22 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 E.

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