By John W. Corcoran (ed.)

The sequence on Antibiotics produced by means of Springer-Verlag begun greater than a decade in the past with the approximately simultaneous visual appeal of 2 volumes, one facing the mode of motion of antibiotics and the opposite in regards to the biosynthesis of them. the factors set by means of the unique Editors have been excessive, and those books have proved precious to many. The speedy advances in our knowl­ fringe of the mode of motion of antibiotics and different antitumor brokers has stimu­ lated additional works within the comparable sequence (Volume III, 1975; and Volumes Vj1 and Vj2, 1979). For a while it had looked as if it would Dr. Konrad Springer that the time may possibly' be ripe' for bringing the topic of the biosynthesis of antibiotics updated. This Editor agreed to survey the literature and speak about this chance together with his colleagues who're lively in examine on antibiotics. inspite of the looks of diverse overview articles, either one of a hugely precise­ ized and basic nature, at the biosynthesis of antibiotics, it was once agreed often that it'd be tremendous invaluable so as to add a brand new quantity on biosynthesis to the sequence. this sort of paintings should still specialize in gathering a gaggle of contributions facing these antibiotics whose biosynthesis is known in a lot higher aspect now than it used to be within the center 1960's. considering the fact that quantity II on biosynthesis remains to be on hand, this addition to the sequence has now not handled each antibiotic whose biosynthesis was once studied lengthy ago.

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30 G. LANCINI and M. GRANDI: HO Demethyl rifamycin SV Rifamycin S H Rifamycin R Rifamycin SV Fig. 13. , 1978). 3. Rifamycin B Family This includes the compounds that have a two-carbon unit of the type -O-CH 2 CO- at position 4 of rifamycin SV or S (Fig. 14). In rifamycin B, the main product of N. mediterranea when grown in the presence of barbital, the chain has the acidic form -OCH 2 COOH. Its origin from rifamycin SV has been demonstrated as mentioned before, by the conversion of labeled SV into 14C-Iabeled rifamycin B, both in N.

1973) Antibiotic 6016 Streptomyces sp. 6016 SETO et al. (1978c) OTAKE et al. (1978a) Class 1b Carriomycin (T42082) Streptomyces hygroscopicus T42082 Dianemycin Streptomyces hygroscopicus NRRL 3444 Etheromycin CP-38295 Streptomyces hygroscopicus Streptomyces hygroscopicus Lenoremycin (Ro 21-6150) (A13OA) Streptomyces hygroscopicus X-14563 OTAKE et al. (1977) IMADA et al. (1978) HAMILL et al. (1969) CZERWINSKI and STEINRAUF (1971) MITANI et al. (1977) CELMER et al. (1976) ATCC 31050 Streptomyces hygroscopicus A130 BLOUNT et al.

14). In rifamycin B, the main product of N. mediterranea when grown in the presence of barbital, the chain has the acidic form -OCH 2 COOH. Its origin from rifamycin SV has been demonstrated as mentioned before, by the conversion of labeled SV into 14C-Iabeled rifamycin B, both in N. mediterranea fermentations and by washed mycelium. , 1969). It is possible that a three-carbon intermediate of glycolysis (such as 3-phosphoglyceric acid or 3-phosphohydroxypyruvate) is first attached to position 4 of rifamycin and then degraded by decarboxylation.

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