By Yang Xia

This precise e-book describes the newest info within the basic knowing of the biophysics and biochemistry of articular cartilage utilizing the cutting-edge practices in NMR and MRI. this is often the 1st ebook of its variety, written by means of physicists and chemists in this vital tissue, whose degradation contributes to osteoarthritis and comparable joint illnesses. Connecting the basic technology with the scientific imaging purposes, the specialists Editors offer an authoritative addition to the literature.
Ideal for training actual scientists and radiologists with an curiosity within the primary technology in addition to tool brands and scientific researchers operating with articular cartilage

Show description

Read Online or Download Biophysics and biochemistry of cartilage by nmr and mri PDF

Similar molecular biology books

Receptor Molecular Biology

The volumes during this sequence comprise modern ideas major to a specific department of neuroscience. they're a useful reduction to the scholar in addition to the skilled researcher not just in constructing protocols in neuroscience yet in disciplines the place examine is changing into heavily on the topic of neuroscience.

Methods in Muscle Biology

Tools in Muscle Biology is a complete laboratory advisor that information the tools utilized in the research of muscle biology. The suggestions incorporated embody cellphone, developmental, and molecular biology, in addition asphysiology, neurobiology, and scientific study.

Principles and Technical Aspects of PCR Amplification

Kary Mullis used to be presented a Nobel Prize for inventing the PCR procedure greater than 15 years in the past in 1993. because its "discovery", a number of variations and adaptations of the normal PCR approach were defined, with lots of those diversifications and adaptations at present getting used in medical, diagnostic and educational laboratories the world over.

Cells Molecules and Mechanisms

The textbook for mobile and molecular biology classes.

Extra resources for Biophysics and biochemistry of cartilage by nmr and mri

Sample text

As the tissue compresses, water is rapidly forced out of the ECM. Tissue volume and the molecular volume of aggrecan domains decrease, while the FCD and the concentration of counter-ion and co-ion species increase, causing increasing intermolecular repulsion and interstitial swelling stress. 6b), a displacement (strain) is applied to the cartilage and maintained at a constant value. As the tissue is compressed, water is forced out from the tissue. The reduction of water content leads to a time-dependent decrease in the interstitial stress as the tissue relaxes.

In the pericellular matrix of each chondrocyte, the concentration of proteoglycan can be two-fold higher than that in the matrix distant from the cells. These proteoglycan macromolecules are rich in polysaccharide side-chains with negatively charged carboxyl and sulfate groups that give articular cartilage a hydrophilic nature. The spatial distribution of GAGs in cartilage can be visualized by using a number of histochemical assays (as well as MRI;85 see chapter 6). 69 This assay is sensitive to interference from proteoglycan core proteins and nonGAG polyanions such as DNA and HA.

21,22 Following the proliferation layer, cells pass through a transition layer (prehypertrophic layer), in which they lose their proliferative ability and gradually increase in size due to swelling. Finally, these cells become hypertrophic and undergo major phenotypic changes,23 following a cascade of events including ECM mineralization, angiogenesis, and cellular apoptosis,20 which eventually lead to the formation of bone. 2 Mature Chondrocytes in Cartilage Mature chondrocytes are the only cell type present in adult articular cartilage.

Download PDF sample

Rated 4.21 of 5 – based on 13 votes