By C.C. Reddy (Eds.)

The 1st of 2 volumes proposing present learn into oxidation structures, this booklet is meant for biochemists, toxicologists, and pharmacologists. themes mentioned comprise the mechanisms of organic oxidations, and peroxidases in mobilephone safety and metabolism

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15. , Simpson, E . R . R. (1986) Science 2 3 4 , 16. , Buczko, E . L. (1988) Biochem 1258-61 Biophys. Res. Commun. 1 5 , 1 5 7 17. , McCarthy, J . L . , 18. , Simpson, E . R . R. (1988) Proc. R. I. (1989) Mol. Endocrinol. 3 , 9 6 8 - 7 5 Natl. Acad. Sci. SA. 8 5 699-703 19. I. W. (1990) in preparation 20. , Higashi, Y . , Hatano, M. and Gotoh, O. (1989) in Cytochrome P-450: Biochemistry and Biophysics. Proceedings of the 6th International Conference (I. ), Taylor and Francis, London, pps. W. Estabrookei al.

15. , Simpson, E . R . R. (1986) Science 2 3 4 , 16. , Buczko, E . L. (1988) Biochem 1258-61 Biophys. Res. Commun. 1 5 , 1 5 7 17. , McCarthy, J . L . , 18. , Simpson, E . R . R. (1988) Proc. R. I. (1989) Mol. Endocrinol. 3 , 9 6 8 - 7 5 Natl. Acad. Sci. SA. 8 5 699-703 19. I. W. (1990) in preparation 20. , Higashi, Y . , Hatano, M. and Gotoh, O. (1989) in Cytochrome P-450: Biochemistry and Biophysics. Proceedings of the 6th International Conference (I. ), Taylor and Francis, London, pps. W. Estabrookei al.

Estabrook et al 32 COS—1 c e l l s c o — t r a n s f e c t e d w i t h : pCD17a pCMVC21 hours Figure 9. The Pattern of Metabolism of Progesterone Seen when Using COS Cells Transfected with Two Different cDNAs for Bovine Adrenal P-450s. One P-450 catalyzes the 17a-hydroxylation of progesterone and the other P-450 catalyzes the 21hydroxylation of progesterone and 17a-OH progesterone. Figure 10. A Schematic Representation of the Potential Pathways of Metabolism of Progesterone Using Two Adrenal P-450s Expressed in Cotransfected COS Cells The P-450 Superfamily 33 STRUCTURAL ANALYSIS OF CYTOCHROME P-450 43 75 116/117/129 I I lili' A Β C D Ε F G Η I - II 320 365 I I ι 1 I 209/219 III I 100|| m I 200 I I 300 | 426 481 I I i | 400 | I M E M B R A N E INSERTION SIGNAL PROLINE RICH S E G M E N T C y t b 5 , KINASE INTERACTION SITE INTERNAL H A L T - T R A N S F E R S E Q U E N C E H Y P E R V A R I A B L E REGION O X Y G E N BINDING S I T E R E D U C T A S E INTERACTION SITE CONSERVED SEGMENT HEME-BINDING REGION Figure 11.

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