By G. C. Steiner (auth.), A. Roessner (eds.)

During the previous few years, a lot of monographs on bone tumors were released. they're quite often limited to bone tumors as clinical-pathological entities, considering the fact that their analysis, greater than that of different tumors, calls for the interdisciplinary cooperation among orthopedic expert, radiologist, and pathologist. even though, investiga­ tions in regards to the histogenesis of bone tumors are quite restricted, even supposing they could be worthwhile in explaining the original morphological heterogeneity of tumors of the skeletal procedure. in addition, the histo­ genetic process within the learn of bone tumors could facilitate the inter­ pretation of the complex cytobiological equipment on hand for improv­ ing type and analysis. hence, this quantity provides fresh pathological advances within the organic characterization of bone tumors. an enormous bankruptcy bargains with the differential prognosis of Ewing's sarcoma as regards its demarcation from the so-called neuroectodermal tumor of bone. The research of the floor components in bone-forming tumors should be precious for his or her type. consequently the quantity contains a bankruptcy at the biochemical and histochemical research of other osteosarcoma varieties. lately it has develop into transparent that during addition to diverse collagen forms which aren't particular for bone tissue, a number of bone-specific proteins take place, one in every of that is osteonectin. Its distribu­ tion is clearly very important for the class and analysis of osteo­ blastic tumors. Proliferative habit is of significant value for the analysis of malignant tumors.

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Despite these two exceptions it can be stated that the demonstration of osteonectin in tumors has proved to be a valuable further parameter in the diagnosis of bone-forming tumors, in particular of osteosarcomas. In combination with the light microscopic findings, a positive osteonectin reaction makes it possible for the pathologist to classify a malignant tumor as an osteosarcoma even if only scanty material is available. 5 Summary Osteonectin is a noncollagenous protein of bone which is believed to be bone specific, since its concentration in bone tissue is 500- to 1000-fold higher than in other connective tissues.

JUNDT Fig. 9a-c. Osteonectin in osteoblastic osteosarcoma. a Classical osteosarcoma with intensively marked atypical osteoblasts adjacent to osteoid islands (x 112). b Higher magnification of classical osteosarcoma showing positive osteoblasts but no immunoreactivity in tumor osteoid (*) (x 300). c Weaker marking of most of the tumor cells in osteoblastic osteosarcoma with scanty matrix production ( x 300). Antiosteonectin, ABC, no counterstaining, Nomarski Immunohistological Demonstration of Osteonectin in Normal Bone Tissue 47 a b Fig.

J Clin Oncol2: 614-624 Young MF, Bolander ME, Day AA, Ramis CI, Gehron Robey P, Yamada Y, Termine JD (1986) Osteonectin mRNA: distribution in normal and transformed cells. Nucleic Acids Res 14:4483-4497 Note added in proof: Meanwhile osteonectin/SPARCfBM-40 immunoreactivity has been demonstrated in decidua and some carcinomas. WEWER UM, ALBRECHTSEN R, FISHER LW, YOUNG ME, TERMINE JD (1988) Am J Pathol132:345-355 Tumor Bone Formation in Different Osteosarcomas: Topological, Biochemical, and Histochemical Analyses J.

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