By J. M. Whitehouse (auth.), Professor Brian W. Fox Ph. D., Dr. Margaret Fox (eds.)
The learn of tumour resistance to anticancer medicinal drugs has been the topic of many courses because the preliminary discovery of the phenomenon by means of J. H. Burchenal and co-workers in 1950. Many papers were released for the reason that then reporting improvement of resistance to many of the recognized anticancer brokers in lots of varied animal tumour platforms, either in vivo and in vitro. many various mechanisms of resistance were defined, and it truly is transparent that the tumour phone has a large variety of techniques in overcoming the cell-killing task of those brokers. Definition of the value of the phenomenon within the hospital is, in spite of the fact that, even more problematic, and it really is with this in brain that the preliminary bankruptcy, seeks to out line the matter because the clinicians see it. it seems that the phenomenon of actual resistance to a drug, because the biochemist could recognize it, is a crucial reason for the failure which clinicians adventure in treating the illness. the level of the contribution of this phenomenon to the failure of remedy can't simply be evaluated today, however it is was hoping that the advance and alertness of recent and extra subtle recommendations for the research of mobile sub populations will help to offer a extra unique estimate and to shed a few mild at the factors of failure of some of the current healing techniques.
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Extra resources for Antitumor Drug Resistance
In a few cases, an increased content of sulfhydryl compounds has been associated with resistance to alkylating agents, though the evidence is not strong. In some cells, inactivation of methotrexate may be a determinant of sensitivity, though again there really is not much evidence on this point. II. Differences in Drug-Target Interaction After a significant concentration of the active form of a drug has been attained within a cell, the drug must then interact in some way with its biochemical "target," which usually is an enzyme or other protein or one or another species of ribo- or deoxyribonucleic acid.
Most studies of this topic have been focused on the resistant tumor cell, and this discussion will continue this emphasis. Before considering biochemical mechanisms in more detail, however, it seems appropriate to note that at least potentially a genetic change in the tumor population could also provide an immunological mechanism of resistance. Thus in the chemotherapy of some tumors growing in noninbred animals, an immunological component has been shown to have a role in the overall therapeutic effect.
Ann Surg 144:366-380 Fisher B, Glass A, Redmond C et al. (1977) L-phenylalanine mustard (L-PAM) in the management of primary breast cancer: an update of earlier findings and a comparison with those utilizing L-PAM plus 5-fluorouracil (5-FU). Cancer 39:2883-903 Fisher RI, DeVita VT, Johnson BL, Simon R, Young RC (1977) Prognostic factors for advanced diffuse histiocytic lymphoma following treatment with combination chemotherapy. Am J med 63: 177 Freireich EJ, Gehan EA (1979) The limitations of the randomised trial.