By Jonathan N. Thon Ph.D., Joseph E. Italiano Ph.D. (auth.), Paolo Gresele, Gustav V. R Born, Carlo Patrono, Clive P. Page (eds.)

Antiplatelet remedy is the cornerstone of therapy of ischemic heart problems and during the last few years dazzling developments during this box were recorded. this can be the 1st entire instruction manual totally devoted to the entire points of antiplatelet remedy. The booklet is split into 3 major sections, pathophysiology, pharmacology and remedy, for a complete of 23 chapters. a wide staff of top specialists from diverse ecu international locations and from america, either from academia and undefined, have contributed to the publication. along with an in depth review at the pharmacology and scientific purposes of all of the at the moment used or of the unconventional antiplatelet brokers, leading edge techniques (e.g. intracellular signalling as an antiplatelet goal, small RNAs as platelet therapeutics, etc.) or unconventional facets (e.g. pharmacologic modulation of the inflammatory motion of platelets also are taken care of. The ebook is orientated to either simple investigators and to clinicians concerned with study on platelet inhibition or with the medical use of antiplatelet therapies.

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1 Collagen Receptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Integrins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Receptors in Amplification Phase . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Receptors in Stabilization Phase . . . . . . . . . . . . . . . . .

References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24 26 27 28 29 29 29 33 37 43 48 50 51 52 Abstract Well-understood functions for “traditional” platelet receptors are described, but “newer” receptors are equally discussed. Receptors are described biochemically (structure, ligand(s), protein partners, and function) and whenever possible, their clinical importance (mutations, polymorphisms, syndrome) are highlighted.

PGI2 Prostacyclin released from endothelial cells PGD2 PGE2 Biochemical Description Four distinct transmembrane proteins, GPIba (135 kDa), GPIbb (26 kDa), GPIX (20 kDa), and GPV (82 kDa), assemble at the surface of bone marrow megakaryocytes to constitute a functional GPIb receptor. 2 (GPIBB), 3q29(GP5), and 3q21 (GP9). These genes belong to the leucine-rich family of proteins and are almost exclusively expressed in platelets, with the exception of faint expression in certain endothelial cells (Wu et al.

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