By J. Lindsay Whitton (auth.), J. Lindsay Whitton M.D., Ph.D. (eds.)

Antigen presentation is principal to the immune reaction, andis instrumental in making sure that the reaction fastened is that most suitable to the eradication of the actual microbe confronted. during this quantity, specialists within the box offer state of the art descriptions of the antigen presentation pathways. How do viruses disrupt those severe pathways, and to what impression? Do all tissues current antigen within the related method? If now not, why? What are the results of dysfunctional antigen presentation, noticeable in convinced genetic issues? This publication considers not just the molecular info, but in addition their relevance to the full organism.

Show description

Read Online or Download Antigen Presentation PDF

Similar nonfiction_9 books

Imaging Living Cells

More advantageous expertise for imaging residing cells, particular mobile ambitions and organelles is having a dramatic effect on easy and utilized study. by way of combining optical layout and molecular genetics, a brand new sequence of instruments is being constructed and effectively utilized including classical probes. Novel labelling thoughts, greater software program for photo enhancement and research at the moment are to be had and make allowance photo acquisition with better velocity and precision.

The Physiological Genomics of the Critically Ill Mouse

The physiological genomics of the cardiovascular approach reports the connection among gene and physiological (dys)function. it's a quickly constructing sector of study and distinguishes itself from different components of molecular medication by way of its hugely integrative nature. during this multi­ disciplinarian quarter of the physiological sciences, there's interplay among gene constitution and physiological cardiovascular functionality in addition to interactions among different organs and their physiological booths.

Econophysics of Wealth Distributions: Econophys-Kolkata I

Figuring out the distribution of source of revenue and wealth in an economic climate has been a vintage challenge in economics for the final hundred years. except the speedily decaying quantity density of individuals with their source of revenue crossing over to a powerful energy legislations for the very wealthy, often called the Pareto power-law, after Vilfredo Pareto.

Extra info for Antigen Presentation

Example text

1996), although this does not necessarily indicate TAP independence. Finally, CD8+ T cells isolated from TAp-/mice are still present in low but significant numbers and possess epitope-specific cytotoxic activity (ALDRICH et al. 1994b; VAN SANTEN et al. 1995; SANDBERG et al. 1996). Peptide affinity for TAP ranges from 410 to 1600 nM, with approximately 105_106 binding sites per cell (VAN ENDERT et al. 1994a; UEBEL et al. 1995; YANG and BRACIALE 1995; KOOPMAN et aI. 1996). Overexpression ofTAPI and TAP2 in insect cells has shown that these two proteins form a heterodimer capable of transporting peptides in the presence of ATP without any requirement for accessory proteins (MEYER et al.

Although the role of ubiquitination and degradation of ubiquitinated proteins by 26S proteasomes in MHC class I antigen processing is tenuous, it is clear that 20S proteasomes playa major role (see above discussion). Once generated, peptides have a remarkably short half-life in cells, but the binding to MHC class I molecules prevents their degradation and extends their half-life (MALARKANNAN et al. 1995b). 2 Peptide Size Digestion of ovalbumin-derived peptides 22-44 amino acids long with proteasomes in vitro resulted in the formation of peptides eight to 11 amino acids long (NIEDERMANN et al.

1995) but not others (HANAU et al. 1994; BRUTKIEWICZ et aI. 1995; HOLCOMBE et al. 1995). Although presentation of most MHC class I-binding peptides is dependent on TAP, some peptides may be delivered to the ER by one or more TAP-independent pathways. A subset of HLA-A2 molecules bind ER translocation signal peptides, which are already present in the ER, thereby circumventing the requirement for TAP (HENDERSON et al. 1992; WEI and CRESSWELL 1992). CTL can also be generated to some viral proteins containing ER insertion sequences (ANDERSON et al.

Download PDF sample

Rated 4.92 of 5 – based on 7 votes