By R. J. Hay (auth.), R. J. Hay MD, MRCP, MRCPath. (eds.)

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Extra resources for Advances in Topical Antifungal Therapy

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It was easier to detect the fungus in a specimen by this method than by the use of light microscopy and mounts stained with various dyes [1, 8]. Also one great disadvantage of direct examination using KOH is avoided with this method, namely the presence of the so-called mosaic fungus, which may be mistaken for a fungus when the specimens are examined by inexperienced personnel, but which do not show in FWA-treated preparations. We believe that the FWA technique gives a substantial increase in sensitivity over the routinely used KOH preparation and that this is especially true for the inexperienced observer.

42 Double-Blind Comparative Trial of Three New Antifungal Cream Formulations in Superficial Candidosis 1. Lalosevic and S. Stettendorf Institute of Dermatology and Venerology, Iv. Milutinovica 85, 11000 Beograd, Yugoslavia Abstract A double-blind randomised comparative trial with three new antimycotic drugs for topical use: bifonazole, oxiconazole and naftifine in the form of cream is presented. The study was performed for the purpose of comparative evaluation regarding efficiency and tolerance.

55 45 n n 30 30 20 · 70 10 10 30 30 Maceration 20 lO 10 10 I woek 2 weeks 3 aoys 2 weeks ollor start oUel encl I week 2 weeks 3 ftoys 2 weoks oner slOft oner end Fig. 1. Occurrence of symptoms during follow up . • , bifonazole ; 0, oxiconazole; 0, naftifine microscopic findings were negative in 21 patients (70%) on bifonazole, 8 patients (27%) on oxiconazole and 2 patients (7%) on naftifine; cultural findings were negative in 28 patients (93%), 26 patients (87%) and 14 patients (47%), respectively at the same time.

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