By J. F. Goodwin (auth.), G. Baroldi M.D., F. Camerini M.D., J. F. Goodwin M.D. (eds.)

This e-book presents a contemporary survey at the pathophysiological and scientific implications of the main common varieties of vehicle- diomyopathies, together with diagnostic instruments and new pharmaco- logical therapeutical techniques. an engaging extra element is the hot facts on immunology on dilated cardiomyo- mypathies and unexpected dying in little ones in addition to center transplantation as ultimum reason of remedy.

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To compare the means of continuous variables, we used Student's t test. Contingency t~bles were analyzed by chi-square test. Sixteen variables (Tables 1, 2), including five radionuclide indices, were considered as potential predictors for the occurrence of disease-related mortality during follow-up. Relative filling volume during the rapid filling period (RFV2) and atrial contribution (Ae) were excluded from multi-variate analysis because these measurements could not be made in 21 patients. Linear discriminant analysis with stepwise variable selection and Wilks' Lambda as the selection and optimisation criteria was used to assess the potential to predict disease-related mortality.

Serial echocardiographic studies in this subgroup of patients [13] have shown left ventricular end-diastolic dimension to increase from 44 mm to 49 mm (mean values), usually remaining less than 55 mm. Maximum left ventricular wall thickness decreased from 21 mm to 15 mm, with the largest change in any single patient being 9 mm; radionuclide angiographic ejection fraction was usually less than 50%. These morphologic and functional changes, which are associated with end-stage depression of left ventricular contractile function, could be due to myocardial ischemia or possibly to progression of the intrinsic cardiomyopathic process.

J Am Coll Cardiol (in press) 26. Spirito P, Watson RM, Maron BJ (1987) Relation betwen extent of left ventricular hypertrophy and occurrence of ventricular tachycardia in hypertrophic cardiomyopathy. Am J Cardiol 60: 1137-1142 24 B. 1. Maron 27. Sanderson IE, Gibson DG, Brown Dl, et al (1978) Left ventricular filling in hypertrophic cardiomyopathy: an angiographic study. Br Heart 1 39:661-670 28. Maron Bl, Spirito P, Green KJ, Wesley YE, Bonow RO, Arce 1 (1987) Noninvasive assessment of left ventricular diastolic function by pulsed Doppler echocardiography in patients with hypertrophic cardiomyopathy.

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