By Michel Grino, Nadia Dakine, Odile Paulmyer-Lacroix, Charles Oliver (auth.), Andrew N. Margioris MD, George P. Chrousos MD (eds.)
New and intriguing recommendations within the fields of adrenal body structure and pathophysiology were rising nearly exponentially, generating a big inflow of latest wisdom. In Adrenal issues, a panel of special physicians and researchers-many energetic individuals to the discoveries-select the main proper new findings and combine them into the present physique of medical wisdom on adrenal pathologies. The publication comprises vital studies of disturbances in cortisol homeostasis, and new strategies concerning adrenal tumors and hereditary adrenal ailments. additionally mentioned are mineralocorticoids and the syndromes of mineralocortoid extra and aldosterone synthase deficiency. A concentrated assessment of the molecular and mobile biology of the adrenal cortices medullae, coupled with a dialogue of the secretion and metabolism of adrenal items, offer a valid physiological beginning for knowing the hot techniques to adrenal disease.
Authoritative and insightful, Adrenal problems offers physicians and scientists with a finished, cutting-edge useful consultant to the devastating ailments of the adrenals which are so usually tricky to diagnose and treat.
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Ikeda Y, et al. Developmental expression of mouse steroidogenic factor-I, an essential regulator of the steroid hydroxylases. Mol Endocrinol 1994; 8:654-662. 55. Parker KL and Schlmmer BP. The role of nuclear receptors in steroid hormone production. Semin Cancer Bioi 1994; 5:317-325. 56. Givens CR, et al. Transcriptional regulation of rat cytochrome P450C 17 expression in mouse Leydig MA-1O and adrenal Y-l cells: identification of a single protein that mediates both basal and cAMPinduced activities.
It is noteworthy that in the mouse four distinct alternatively spliced products are derived from the ftz-F1 gene (154). These four different transcripts, ELPs 1, 2, 3, and SF-I, are generated by alternative use of nested promoters and splice sites. Functional studies of these transcripts, using cotransfection experiments in NIH-3T3 cells, showed that although ELP 1 isoform, which lacks the AF2 domain, repressed the transcription of a reporter construct containing the SF-iIELP response element, ELP Isoforms 2 and 3 activated transcription of this construct.
J Clin Endocrino1 Metab 1995; 80:3201-3208. 85. Albrecht ED, Henson MC, and Pepe GJ. Regulation of placental low density lipoprotein uptake in baboons by estrogen. Endocrinology 1991; 128:450-458. 36 Ramayya 86. Leavitt MG, Albrecht ED, and Pepe GJ. Development of the baboon fetal adrenal gland: regulation of the ontogenesis of the definitive and transitional zones by adrenocorticotropin. J Clin Endocrinol Metab 1999; 84:3831-3835. 87. Pepe GJ and Albrecht ED. Central integrative role of oestrogen in the regulation of placental steroidogenic maturation and the development of the fetal pituitary-adrenocortical axis in the baboon.