By Privatdozentin Dr. med. Ursula Creutzig (auth.), Privatdozentin Dr. med. Ursula Creutzig, Professor Dr. med. Jörg Ritter, Professor Dr. med. Günther Schellong (eds.)

The result of remedy for early life acute myelogenous leukemia (AML) have greater significantly over the past ten years. This growth was once proven by means of the 2 consecutive multicenter experiences, AML-BFM-78 and -83, within which virtually exact prolonged multi drug regimes of che­ motherapy have been administered for 8 weeks and up via years upkeep. the most distinction within the moment examine was once the addition of an eight-day extensive in­ duction path. because of this new aspect, the relapse fee used to be lowered considerably. one other results of the BFM-83 examine used to be the definition of 2 possibility teams at the foundation of standardized therapy, which has result in a risk-adapted therapy procedure within the 3rd ongoing trial, AML-BFM- 87. This development was once basically attainable because of the coop­ eration of pediatricians, physicians, radiotherapists, statisti­ cians, and particularly the employees on the hospitals and reference laboratories. hence, we want to thank everybody who has been desirous about those reports and wish that they are going to be additional inspired to enhance remedy thoughts for AML in youngsters. The coordination, enforcement, and analyses of the stud­ ies do not have been attainable with out the monetary sup­ port of the Federal Ministry for study and know-how of the FRG. we're thankful for the beneficiant contributions aiding this ebook from Lederle and Farmitalia. Munster, April 1990 Ursula Creutzig Jorg Ritter Gunther Schellong Contents 1 creation . . . . .. . . . . . . . . . . . . . . .. . . . 1 .

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Extra resources for Acute Myelogenous Leukemia in Childhood: Implications of Therapy Studies for Future Risk-Adapted Treatment Strategies

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8a); an abnormal morphology was found predominantly in patients with ~ 5% eosinophils. In the other F AB types, the percentage of children with ~ 5% eosinophils was low and abnormal eosinophilic cells were rarely seen (Fig. 8b). , X2 test). Cytochemistry. Quantitative information on the cytochemical reactions POX and ANAE is available only for AML-BFM-83 (Table 11). In those FAB types with predominantly granulocytic differentiation (MlM4), the POX reaction, with one exception, was always positive (116/ 117 patients).

I- 3 N N - 4 30 41 5 6 7 8 9 YEARS 11 IN CCR ) 12 IN CCR ) o It: II. •. - AML-BFM 83 ( N - 20 31 11 IN CCR ) 12 IN CCR ) Fig. 17. a Probability of EFS duration in patients with FAB MS, AML-BFM-78 vs. AML-BFM-83. b Same for EFI duration FAB M7. Out of three patients with acute megakaryoblastic leukemia in AML-BFM-83, one was in CCR for 28 months; the other two died within five months after achieving partial remission or suffering early relapse. Results 46 >..... l. -~---r- o FAB 6 ( N 2 = 10; 3 4 5 YEARS 4 IN CCR ) Fig.

12 and 13. FAB MI. In both studies, the results for an EFS (Fig. 8 II: ':;'. ""_.. L~ 0 ~ Q. ' 9. S2 ( SD - 9. 08 ) l\. 07 5 S YERRS CCR CCR CCR CCR H II: 0 ~ Q. 91 9 FRB 1 ......... 9S 5 S YERRS CCR CCR CCR CCR Fig. 13. a Probability of EFS duration in the FAB types MI, M2, M4, and M5 (AMLBFM-83). 09), (Fig. 19). FAB M2. At 30/37 children (81%), the proportion of M2 patients whq entered remission was lower in AML-BFM-83 than in AML-BFM-78 (33/34 patients, 97%) (Fig. 15a); however, few relapses occurred in AML-BFM-83.

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